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In the phase 2 dose-escalation study (Jastreboff et al., NEJM, 2023), gastrointestinal adverse events were reported in a substantial proportion of participants, with incidence increasing at higher doses
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Dosage:3.6mg/10mg
Teneligliptin, a DPP-4 inhibitor, demonstrated mild antinociceptive effects against heat-induced acute pain, but remarkable analgesic effects against partial sciatic nerve transection (PSNT)-induced neuropathic pain in rats [70]
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